Message type: E = Error
Message class:  V4 - Nachrichten Verkauf (Variable Meldungen und EDI-Meldungen) 
Message number: 216
Message text: Billing documents can only be canceled completely
Cancellation document &V1& sent in by the customer does not contain all
of the items in the billing document that are due to be cancelled.
The cancellation document does not contain item &V4& from billing
document &V3& (external document &V2&)
The system terminates processing of the intermediate document (IDoc).
Add the missing item to the IDoc and process it again.
Error message extract from SAP system. Copyright SAP SE.
The SAP error message V4216, which states "Billing documents can only be canceled completely," typically occurs when you attempt to cancel a billing document that cannot be partially canceled. This error is common in scenarios where the billing document is linked to a sales order or delivery that has already been processed in a way that does not allow for partial cancellations.
Cause: Complete Cancellation Requirement: The billing document is set up in such a way that it can only be canceled in its entirety. This is often the case with certain types of billing documents, such as invoices that have already been settled or linked to financial transactions. Document Status: The status of the billing document may not allow for partial cancellations. For example, if the document has been fully paid or if it is linked to a completed sales order, SAP may restrict any form of cancellation other than a complete
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